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HRID568242

反应详情

EQUATION

反应方程式

HRID 568242 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)[Si](C)(C)OCCOS(=O)(=O)C(F)(F)F
HCID15678107

2-{[tert-Butyl(dimethyl)silyl]oxy}ethyl trifluoromethanesulfonate

C9H19F3O4SSi

结构：C=CCOC(=O)C1=C(S[C@H]2C[C@@H](Cc3cn4cncc4s3)N(C(=O)OCC=C)C2)[C@H](C)[C@@H]2[C@@H]([C@@H](C)O)C(=O)N12
HCID131722333

未命名化合物

PRODUCTS

生成物

1
结构：C=CCOC(=O)C1=C(S[C@H]2C[C@@H](Cc3c[n+]4cn(CCO[Si](C)(C)C(C)(C)C)cc4s3)N(C(=O)OCC=C)C2)[C@H](C)[C@@H]2[C@@H]([C@@H](C)O)C(=O)N12.O=S(=O)([O-])C(F)(F)F
HCID178459460

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(Cl)Cl
溶剂HCID6365

1,1-Dichloroethane

C2H4Cl2

PROCEDURE

实验过程

2-(t-Butyldimethylsilyloxy)ethyl trifluoromethanesulfonate (20.9 mg) is added to a solution of 32.3 mg of allyl(1R,5S,6S)-2-[(3S,5S)-1-allyloxycarbonyl-5-(imidazo[5,1-b]thiazol-2-yl)methylpyrrolidin-3-yl]thio-6-((1R)-1-hydroxyethyl)-1-methylcarbapen-2-em-3-carboxylate described in Example 23-a) in 0.5 ml of dry dichloroethane, and the mixture is stirred in an argon atmosphere at room temperature for 2 hr. The excess reagent is removed by evaporation under reduced pressure to give allyl(1R,5S,6S)-2-[(3S,5S)-1-allyloxycarbonyl-5-[6-(2-t-butyldimethylsilyloxyethyl)imidazo[5,1-b]thiazolium-2-yl]methylpyrrolidin-3-yl]thio-6-((1R)-1-hydroxyethyl)-1-methylcarbapen-2-em-3-carboxylate trifluoromethanesulfonate as a brown viscous material.

WORKUP

后处理

  1. customThe excess reagent is removed by evaporation under reduced pressure