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HRID568250

反应详情

EQUATION

反应方程式

HRID 568250 的结构方程式

REACTANTS

反应物

2
结构：O=S(=O)(OCCF)C(F)(F)F
HCID13638935

未命名化合物

结构：C=CCOC(=O)C1=C(S[C@H]2C[C@@H](Cc3cn4c(C)ncc4s3)N(C(=O)OCC=C)C2)[C@H](C)[C@@H]2[C@@H]([C@@H](C)O)C(=O)N12
HCID131722343

未命名化合物

PRODUCTS

生成物

1
结构：C=CCOC(=O)C1=C(S[C@H]2C[C@@H](Cc3c[n+]4c(C)n(CCF)cc4s3)N(C(=O)OCC=C)C2)[C@H](C)[C@@H]2[C@@H]([C@@H](C)O)C(=O)N12.O=S(=O)([O-])C(F)(F)F
HCID178459453

未命名化合物

收率 89.2%

PROCEDURE

实验过程

2-Fluoroethyl trifluoromethanesulfonate (40.6 mg) is added to 30.6 mg of allyl(1R,5S,6S)-2-[(3S,5S)-1-allyloxycarbonyl-5-(5-methylimidazo[5,1-b]thiazol-2-yl)methylpyrrolidin-3-yl]thio-6-((1R)-1-hydroxyethyl)-1-methylcarbapen-2-em-3-carboxylate described in Example 31-a), and the mixture is stirred in an argon atmosphere at room temperature for 3.5 hr. The solvent is removed by evaporation under reduced pressure. The residue is purified by column chromatography on Sephadex LH-20 (dichloromethane:methanol=1:1) to give 36.4 mg of allyl(1R,5S,6S)-2-[(3S,5S)-1-allyloxycarbonyl-5-[6-(2-fluoroethyl)-5-methylimidazo[5,1-b]thiazolium-2-yl]methylpyrrolidin-3-yl]thio-6-((1R)-1-hydroxyethyl)-1-methylcarbapen-2-em-3-carboxylate trifluoromethanesulfonate as a yellow oil.

WORKUP

后处理

  1. customThe solvent is removed by evaporation under reduced pressure
  2. customThe residue is purified by column chromatography on Sephadex