Nitric Acid → 3-Nitro-4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine

HRID 570223Notes

Reaction equation

HRID 570223 reaction equation
S(=O)(=O)(O)O.[F:6][C:7]([F:26])([F:25])[C:8]1[CH:13]=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[C:20]([F:23])([F:22])[F:21])[N:11]=[C:10]([NH2:24])[CH:9]=1.[N+:27]([O-])([OH:29])=[O:28].[OH-].[Na+]>>[N+:27]([C:9]1[C:10]([NH2:24])=[N:11][C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[C:20]([F:22])([F:21])[F:23])=[CH:13][C:8]=1[C:7]([F:6])([F:25])[F:26])([O-:29])=[O:28]

Participants

5

Reactant 4

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 866574094-Trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine

Product 1

HCID 866574103-Nitro-4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine

Conditions

Temperature
0 °C

Procedure

Sulfuric acid (10 mL) was placed in a 100 mL two-necked round-bottomed flask fitted with a magnetic stir bar and an internal thermometer and cooled to 0° C. 4-Trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine (720 mg, 2.35 mmol, prepared as described in STEP C above) was added portion wise so that the internal temperature did not exceed 5° C. The resulting mixture was stirred at 0° C. for 1 h. Nitric acid (106 μL, 2.35 mmol) was added slowly, keeping the internal temperature below 10° C. The mixture was stirred an additional 2 h at 0° C., poured over ice water (100 mL), treated with 6 M aqueous NaOH to pH 10, and extracted twice with EtOAc (100 mL). The combined organic extracts were dried over MgSO4 and concentrated in vacuo. The residue was purified on a 24-g SEPRA Si 50 SPE column (Flow rate=20 mL/min; Eluent=EtOAc-hexanes, 1:99 for 10 min, then 1:99 to 1:3 over 40 min) to yield 3-nitro-4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine as a bright yellow solid. Mass Spectrum (LCMS, APCI pos.): Calculated for C13H7N3O2F6: 352.0 (M+H); Measured: 352.0.

Workup

  1. customfitted with a magnetic stir bar
  2. customdid not exceed 5° C
  3. customthe internal temperature below 10° C
  4. stirringThe mixture was stirred an additional 2 h at 0° C.
  5. extractionextracted twice with EtOAc (100 mL)
  6. dry with materialThe combined organic extracts were dried over MgSO4
  7. concentrationconcentrated in vacuo
  8. customThe residue was purified on a 24-g SEPRA Si 50 SPE column (Flow rate=20 mL/min
  9. waitEluent=EtOAc-hexanes, 1:99 for 10 min

Sources & evidence

ORD record
ord-99d4ef370df144ef9179ea1cad7bfa28
Source dataset
uspto-grants-2015_05
Patent number
US09023846B2

Reaction notes

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