tert-Butyl (3-aminopropyl)carbamate → HCID 70795649, compound

HRID 570448Notes

Reaction equation

HRID 570448 reaction equation
N[CH2:2][CH2:3][NH:4][C:5]([C:7]1[S:8][CH:9]=[CH:10][C:11]=1[NH:12][C:13]1[CH:18]=[CH:17][N:16]=[C:15]2[NH:19][CH:20]=[CH:21][C:14]=12)=[O:6].[C:22]([NH:29]CCCN)(OC(C)(C)C)=O>>[NH2:29][CH2:22][CH2:2][CH2:3][NH:4][C:5]([C:7]1[S:8][CH:9]=[CH:10][C:11]=1[NH:12][C:13]1[CH:18]=[CH:17][N:16]=[C:15]2[NH:19][CH:20]=[CH:21][C:14]=12)=[O:6]

Participants

3

Reactant 2

HCID 2735700tert-Butyl (3-aminopropyl)carbamateHCID 509244533-(1H-Pyrrolo[2,3-b]pyridin-4-ylamino)-thiophene-2-carboxylic acid (2-amino-ethyl)-amide

Product 1

HCID 70795649HCID 70795649, compound

Procedure

This compound was prepared in an analogous manner as 3-(1H-Pyrrolo[2,3-b]pyridin-4-ylamino)-thiophene-2-carboxylic acid (2-amino-ethyl)-amide using 3-(Boc-amino)-propylamine instead of tert-butyl-2-amino ethyl carbamate. LCMS (ESI) 316 (M+H) 1H NMR (400 MHz, DMSO-d6) δ ppm 12.47 (1H, br. s.) 10.84 (1H, s) 8.66 (1H, t, J=5.56 Hz) 8.04 (1H, d, J=6.83 Hz) 7.87 (3H, d, J=5.27 Hz) 7.36-7.42 (1H, m) 7.30 (1H, d, J=5.27 Hz) 6.81 (1H, br. s.) 6.67 (1H, d, J=7.03 Hz) 3.23 (2H, q, J=6.44 Hz) 2.66-2.82 (2H, m) 1.67-1.81 (2H, m)

Sources & evidence

ORD record
ord-9108f4f386aa4efba8725ed5ed384578
Source dataset
uspto-grants-2015_05
Patent number
US09023847B2

Reaction notes

Loading…