2-(Benzyloxy)ethanamine → HCID 50924762, compound

HRID 570449Notes

Reaction equation

HRID 570449 reaction equation
N[CH2:2][CH2:3][NH:4][C:5]([C:7]1[S:8][CH:9]=[CH:10][C:11]=1[NH:12][C:13]1[CH:18]=[CH:17][N:16]=[C:15]2[NH:19][CH:20]=[CH:21][C:14]=12)=[O:6].[CH2:22]([O:29]CCN)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:22]([O:29][CH2:2][CH2:3][NH:4][C:5]([C:7]1[S:8][CH:9]=[CH:10][C:11]=1[NH:12][C:13]1[CH:18]=[CH:17][N:16]=[C:15]2[NH:19][CH:20]=[CH:21][C:14]=12)=[O:6])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 5338682-(Benzyloxy)ethanamineHCID 509244533-(1H-Pyrrolo[2,3-b]pyridin-4-ylamino)-thiophene-2-carboxylic acid (2-amino-ethyl)-amide

Product 1

HCID 50924762HCID 50924762, compound

Procedure

This compound was prepared in an analogous manner as 3-(1H-Pyrrolo[2,3-b]pyridin-4-ylamino)-thiophene-2-carboxylic acid (2-amino-ethyl)-amide using 2-(benzyloxy)ethanamine instead of tert-butyl-2-amino ethyl carbamate. LCMS (ESI) 393 (M+H) 1H NMR (400 MHz, DMSO-d6) δ ppm 11.51 (1H, br. s.) 10.24 (1H, s) 8.15 (1H, s) 7.99 (1H, d, J=5.47 Hz) 7.76 (1H, d, J=5.27 Hz) 7.44 (1H, d, J=5.47 Hz) 7.16-7.32 (5H, m) 6.78 (1H, d, J=5.27 Hz) 6.41 (1H, d, J=3.32 Hz) 4.44 (2H, s) 3.48-3.56 (2H, m) 3.39-3.47 (2H, m)

Sources & evidence

ORD record
ord-1efb9ebbffa04d0dabae84d805389c30
Source dataset
uspto-grants-2015_05
Patent number
US09023847B2

Reaction notes

Loading…