反应详情

35 mg (0.07 mmol) of 2-[1-(2-fluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-4-iodo-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one were dissolved in 8 ml of absolute DMF, 50 mg of 10% palladium on charcoal were added and hydrogenation was effected under standard hydrogen pressure overnight. The reaction mixture was filtered through Celite and concentrated. The residue was stirred with 1 ml of acetonitrile and filtered with suction, and the solids were dried under high vacuum. 5 mg of the target compound were obtained (purity 92%; 17% of theory).

1. custompressure overnight
2. filtrationThe reaction mixture was filtered through Celite
3. concentrationconcentrated
4. filtrationfiltered with suction
5. customthe solids were dried under high vacuum