Hydrochloric Acid → HCID 86681752, compound

A mixture of tert-butyl 2-(5-cyano-1,3-dioxoisoindolin-2-yl)acetate (0.440 g, 1.537 mmol), aqueous 1M HCl (0.768 ml, 0.768 mmol) and 10% w/w Pd/C (a catalytic amount) in MeOH (30 ml) was hydrogenated in a Parr apparatus at 40 psi for 4 hours. 37% HCl aqueous solution (0.0316 ml, 0.384 mmol) was added, and the mixture hydrogenated at 45 psi for additional 4 hours. The mixture was filtered, and the solution evaporated under vacuum. The crude was dissolved in MeOH (25 ml) and added to a suspension of new 10% w/w Pd/C (a catalytic amount) in MeOH (5 ml); 37% HCl (0.0316 ml, 0.384 mmol) was added at 0° C., and the mixture was hydrogenated at 45 psi 3 hours. The catalyst was filtered off, and the solution concentrated under vacuum. The crude was triturated with diethyl ether to afford tert-butyl 2-(5-(aminomethyl)-1,3-dioxoisoindolin-2-yl)acetate hydrochloride (0.409 g, 1.252 mmol, 81% yield, MS/ESI+ 291.1 [MH]+).

1. waitthe mixture hydrogenated at 45 psi for additional 4 hours
2. filtrationThe mixture was filtered
3. customthe solution evaporated under vacuum
4. dissolutionThe crude was dissolved in MeOH (25 ml)
5. additionadded to a suspension of new 10% w/w Pd/C (a catalytic amount) in MeOH (5 ml)
6. customwas hydrogenated at 45 psi 3 hours
7. filtrationThe catalyst was filtered off
8. concentrationthe solution concentrated under vacuum
9. customThe crude was triturated with diethyl ether

ORD record

ord-1c373ec846944457a2560880611722fa

Source dataset

uspto-grants-2015_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09024027B2