反应详情

The title compound was prepared according to the procedure described for the preparation of compound “8” by using 6-{4-[1-(2-azetidin-1-yl-ethyl)-4-(2-isopropyl-pyridin-4-yl)-1H-imidazol-2-yl]-piperidin-1-yl}-5-bromo-pyrimidin-4-ylamine and benzenboronic acid as the starting materials. LC-MS (M+H=523, obsd=523). 1H NMR (400 MHz, DMSO-d6) δ 8.37 (dd, J=5.1, 0.8 Hz, 1H), 8.08 (s, 1H), 7.76 (s, 1H), 7.54-7.46 (m, 3H), 7.43 (dd, J=5.1, 1.6 Hz, 1H), 7.36 (dddd, J=9.9, 6.5, 2.9, 1.6 Hz, 3H), 5.65 (s, 2H), 3.83 (t, J=6.2 Hz, 2H), 3.79-3.66 (m, 2H), 3.09 (t, J=7.0 Hz, 4H), 3.00 (h, J=6.9 Hz, 1H), 2.92-2.79 (m, 1H), 2.69 (dd, J=20.7, 7.0 Hz, 1H), 1.92 (p, J=7.0 Hz, 2H), 1.59 (dt, J=8.0, 4.5 Hz, 4H), 1.25 (d, J=6.9 Hz, 6H).

1. customdescribed for the preparation of compound “8”