反应详情

温度

50 °C

A mixture of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (2.0 g, 10. mmol), tert-butyl 3-(cyanomethylene)azetidine-1-carboxylate (2.0 g, 10. mmol) (Example 2, Step 2) and 1,8-diazabicyclo[5.4.0]undec-7-ene (1 mL, 7 mmol) in acetonitrile (3 mL) was stirred at 50° C. overnight. After cooling the mixture was concentrated under reduced pressure. The residue was purified by flash chromatography on a silica gel column with ethyl acetate in hexane (0-50%) to afford the desired product (quantitative). LCMS (M+Na)+: m/z=411.2; (M-C4H9)+: m/z=333.1.

1. temperatureAfter cooling the mixture
2. concentrationwas concentrated under reduced pressure
3. customThe residue was purified by flash chromatography on a silica gel column with ethyl acetate in hexane (0-50%)