反应详情

The title compound of Example 141 was prepared in similar manner as described in Example 134 except the key intermediate (R)-tert-butyl 3-((R)-2-(3-chloro-5-fluorophenylamino)-2-cyclopropylacetamido)piperidine-1-carboxylate was replaced with (R)-tert-butyl 3-(2-(3,5-dichlorophenylamino)acetamido)piperidine-1-carboxylate and the 4-amino-6-chloropyrimidine-5-carbonitrile was substituted for N-(6-chloropyrimidin-4-yl)acetamide. 1H NMR (400 MHz, DMSO-d6) δ 10.32 (s, 1H), 8.17 (s, 1H), 7.96 (d, J=7.78 Hz, 1H), 6.56 (t, J=1.88 Hz, 1H), 6.47 (d, J=1.76 Hz, 2H), 4.02 (br. s., 1H), 3.79 (br. s., 1H), 3.61 (d, J=9.29 Hz, 3H), 2.84-3.17 (m, 2H), 2.00 (s, 3H), 1.75 (br. s., 2H), 1.33-1.57 (m, 2H). EIMS (m/z): calcd. for C19H22Cl2N6O2 (M+1H) 437. found 437.