反应详情

Prepared from N-Methoxy-N-methyl-4-(5-trifluoromethyl-isoxazol-3-yl)-benzamide and a 1.7 N THF solution of tert-butylmagnesium bromide as described in Example 5. Chromatographed on silica gel with EtOAc/hexanes (5 then 10%) as eluant to afford product as a colorless solid (21 mg, 7%). 1H NMR (CDCl3) 1.37 (s, 9H), 7.05 (s, 1H), 7.79 (d, J=8.4, 2H), 7.87 (d, J=7.9, 2H). 19F NMR −64.6. LC/MS 7.28 min, [M+1]+ 298.

1. customChromatographed on silica gel with EtOAc/hexanes (5