反应详情

温度

90 °C

To a stirred solution of ethyl 4-amino-2-bromo-6-methyl-3-(3-methyl phenyl)thieno[2,3-b]pyridine-5-carboxylate (Description 58) (900 mg, 2.221 mmol) in ethanol (20 mL) at RT was added aqueous NaOH (5M) (1.0 mL, 5.0 mmol). The reaction mixture was heated to 90° C. for ca. 2 h. After cooling to RT the solvent was removed in vacuo. The residue was re-dissolved in water (ca. 80 mL) and neutralized to ca. pH 7 using aqueous HCl (5M). The solution was then extracted with 20% MeOH in DCM (ca. 50 mL×2). The combined organic layer was passed through a phase separator and the solvent removed in vacuo to give a residue which was subsequently re-dissolved in diphenyl ether (10 mL, 62.9 mmol) and heated to 200° C. for ca. 3 h. The reaction mixture was cooled to RT, passed through an SCX cartridge (eluting with MeOH/2M NH3 MeOH). The basic fractions were combined and the solvent removed in vacuo, to give the title compound (487 mg). LCMS (A) m/z: 333/335 [M+1]+, Rt 0.86 min (acidic).

1. temperatureAfter cooling to RT the solvent
2. customwas removed in vacuo
3. dissolutionThe residue was re-dissolved in water (ca. 80 mL)
4. extractionThe solution was then extracted with 20% MeOH in DCM (ca. 50 mL×2)
5. customthe solvent removed in vacuo
6. customto give a residue which
7. temperatureheated to 200° C. for ca. 3 h
8. temperatureThe reaction mixture was cooled to RT
9. washpassed through an SCX cartridge (eluting with MeOH/2M NH3 MeOH)
10. customthe solvent removed in vacuo