反应详情

温度

0 °C

Into a 2000-mL 4-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen was placed a solution of 1-bromo-2-fluoro-4-iodobenzene (58 g, 192.76 mmol, 1.00 equiv) in tetrahydrofuran (600 mL), followed by the addition of i-PrMgCl (96.3 mL, 1.00 equiv) dropwise with stirring at 0° C. over 30 min. The mixture was stirred at 0° C. for 3 h. To this was added tert-butyl 3-oxocyclobutane-1-carboxylate (32.7 g, 192.12 mmol, 1.00 equiv) dropwise with stirring at −78° C. over 10 min. The mixture was stirred at −78 degree C. for 1 h and overnight at room temperature. The reaction was then quenched by the addition of 200 mL of saturated aqueous NH4Cl at 0° C. and extracted with 3×500 mL of ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under vacuum to afford 62 g (crude) of tert-butyl 3-(4-bromo-3-fluorophenyl)-3-hydroxycyclobutane-1-carboxylate as a yellow oil.

1. customInto a 2000-mL 4-necked round-bottom flask purged
2. temperaturemaintained with an inert atmosphere of nitrogen
3. stirringThe mixture was stirred at 0° C. for 3 h
4. stirringwith stirring at −78° C. over 10 min
5. stirringThe mixture was stirred at −78 degree C
6. waitfor 1 h
7. customovernight
8. customat room temperature
9. customThe reaction was then quenched by the addition of 200 mL of saturated aqueous NH4Cl at 0° C.
10. extractionextracted with 3×500 mL of ethyl acetate
11. dry with materialdried over anhydrous sodium sulfate
12. concentrationconcentrated under vacuum