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HRID575336

反应详情

EQUATION

反应方程式

HRID 575336 的结构方程式

REACTANTS

反应物

2
结构：C#CC1(O)CCCC1
HCID87074

Cyclopentanol, 1-ethynyl-

C7H10O

结构：CC(C)(O)Cn1cc(-c2c(C(N)=O)nc3n2C2CC(C2)c2ccc(Br)cc2-3)cn1
HCID86693364

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(O)Cn1cc(-c2c(C(N)=O)nc3n2C2CC(C2)c2ccc(C#CC4(O)CCCC4)cc2-3)cn1
HCID86693370

未命名化合物

PROCEDURE

实验过程

10-bromo-3-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-6,7-dihydro-5H-5,7 methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamide was reacted with 1-ethynylcyclopentanol via General Procedure E to afford 20 mg (14.5%) of 3-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-10-((1-hydroxycyclopentyl)ethynyl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamide following reverse phase purification. M+1=486.

WORKUP

后处理

  1. customto afford
  2. custom20 mg (14.5%) of 3-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-10-((1-hydroxycyclopentyl)ethynyl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2-carboxamide following reverse phase purification