反应详情

A solution of tert-butyl 4,4-difluoro-3-((7-(4-((2-hydroxyethyl)(methyl)amino)phenyl) pyrido[4,3-b]pyrazin-5-ylamino)methyl)piperidine-1-carboxylate (25 mg, 0.05 mmol) and 2 mL of HCl-EA (5.0 N) in 4 mL of EA was stirred at room temperature for 1.5 hours. The volatiles were removed in vacuo, and the residue was added to 5 mL of MeOH and 0.5 mL of NH3.H2O. The volatiles were removed in vacuo, and the residue was purified by chromatography with MeOH/H2O (1:10-5:1) to give 14 mg of title compound. MS (m/z)=429 (M+H)+.

1. customThe volatiles were removed in vacuo
2. additionthe residue was added to 5 mL of MeOH and 0.5 mL of NH3.H2O
3. customThe volatiles were removed in vacuo
4. customthe residue was purified by chromatography with MeOH/H2O (1:10-5:1)