反应详情

Following the procedures as described in Example 61 and starting with tert-butyl 4-(6-(6-(1H-pyrazol-4-yl)-1H-pyrazolo[4,3-c]pyridin-1-yl)pyridin-2-yl)-1,4-diazepane-1-carboxylate and 1,1-difluoro-2-iodoethane, 162 was obtained as a light yellow solid (21 mg, 14.5%) over two steps. 1H NMR (500 MHz, CDCl3) δ (ppm) 9.060-9.062 (d, J=1 Hz, 1H), 8.74 (s, 1H), 8.24 (s, 1H), 8.11 (s, 1H), 8.04 (s, 1H), 7.61-7.64 (t, J=16 Hz, 1H), 7.26-7.28 (t, J=10.5 Hz, 1H), 6.42-6.44 (d, J=8.5 Hz, 1H), 6.04-6.26 (m, 1H), 4.51-4.57 (m, 2H), 3.89-3.93 (m, 4H), 3.17-3.19 (t, J=11 Hz, 2H), 2.92-2.94 (t, J=11 Hz, 2H), 2.02-2.05 (m, 2H); MS (ESI) m/z: 425 [M+H]+.