反应详情

The title compound was prepared in a manner similar to Example 227 using 6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 4-(methoxymethyl)piperidine hydrochloride. 1H NMR (400 MHz, DMSO-d6) δ 1.10 (qd, J=12.3, 4.0 Hz, 2 H) 1.59 (br. s., 1 H) 1.67 (br. s., 1 H) 1.70-1.85 (m, 1 H) 2.36 (s, 3 H) 2.74 (br. s., 1 H) 3.14 (d, J=6.3 Hz, 2 H) 3.17 (s, 3 H) 3.57 (br. s., 1 H) 4.41 (br. s., 1 H) 7.57 (dd, J=8.0, 1.4 Hz, 1 H) 7.64 (s, 1 H) 7.74 (d, J=8.1 Hz, 1 H) 7.96 (dd, J=8.6, 2.3 Hz, 1 H) 8.03-8.09 (m, 1 H) 8.31 (d, J=8.3 Hz, 1 H) 8.42-8.47 (m, 1 H) 13.03 (br. s., 1 H). MS m/z [M+H]+ 432.5.