反应详情

The title compound was prepared in a manner similar to Example 303 using 6-(4-(4-cyano-3-fluoro-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and (R)-1-ethyl-2-methylpiperazine. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.22 (m, J=7.20, 7.20 Hz, 6H) 2.33 (d, J=2.27 Hz, 3 H) 2.91-4.72 (m, 9 H) 7.63 (br. s., 1 H) 7.71-7.79 (m, 1 H) 7.94-8.81 (m, 4 H) 9.52-10.21 (m, 1 H). ESI-MS m/z [M+H]+ 449.3.