6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridine → (S)-(2-(3-aminopiperidin-1-yl)-6-(6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridin-1-yl)pyridin-3-yl)methanol

HRID 57919Notes

Reaction equation

HRID 57919 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([C:8]2[N:13]=[CH:12][C:11]3[CH:14]=[N:15][NH:16][C:10]=3[CH:9]=2)[CH:5]=[N:4][CH:3]=1.Br[C:18]1[N:23]=[C:22]([N:24]2[CH2:29][CH2:28][CH2:27][C@H:26]([NH:30]C(=O)OC(C)(C)C)[CH2:25]2)[C:21]([CH2:38][OH:39])=[CH:20][CH:19]=1>>[NH2:30][C@H:26]1[CH2:27][CH2:28][CH2:29][N:24]([C:22]2[C:21]([CH2:38][OH:39])=[CH:20][CH:19]=[C:18]([N:16]3[C:10]4[CH:9]=[C:8]([C:6]5[CH:5]=[N:4][CH:3]=[C:2]([CH3:1])[N:7]=5)[N:13]=[CH:12][C:11]=4[CH:14]=[N:15]3)[N:23]=2)[CH2:25]1

Participants

3

Reactant 2

HCID 867070806-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridineHCID 86707108tert-butyl N-[(3S)-1-[6-bromo-3-(hydroxymethyl)-2-pyridyl]-3-piperidyl]carbamate

Product 1

HCID 86707109(S)-(2-(3-aminopiperidin-1-yl)-6-(6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridin-1-yl)pyridin-3-yl)methanolYield 68%

Procedure

Following the procedures as described in EXAMPLE 86 and starting with 6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridine and tert-butyl N-[(3S)-1-[6-bromo-3-(hydroxymethyl)-2-pyridyl]-3-piperidyl]carbamate, 218 was obtained as an off-white solid (40.8 mg, 68%) over 2 steps. 1H NMR (400 MHz, DMSO) δ 9.77-9.73 (s, 1H), 9.49-9.45 (s, 1H), 9.34-9.31 (s, 1H), 8.69-8.67 (s, 1H), 8.64-8.61 (s, 1H), 8.03-7.98 (d, J=8.1 Hz, 1H), 7.65-7.61 (d, J=8.1 Hz, 1H), 4.59-4.52 (d, J=2.9 Hz, 2H), 3.60-3.52 (d, J=12.4 Hz, 1H), 3.51-3.43 (d, J=9.8 Hz, 1H), 3.21-3.15 (d, J=10.4 Hz, 1H), 3.00-2.92 (s, 1H), 2.74-2.68 (d, J=12.0 Hz, 1H), 2.67-2.64 (s, 3H), 1.98-1.89 (d, J=9.4 Hz, 2H), 1.77-1.66 (m, 1H), 1.37-1.26 (d, J=10.0 Hz, 1H); MS (ESI) m/z: 417.1 [M+H]+

Sources & evidence

ORD record
ord-a442459d66184d25af6769b86361b5ef
Source dataset
uspto-grants-2016_09
Patent number
US09434725B2

Reaction notes

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