反应详情

Ethyl 2-{4-[(9R)-9-hydroxy-2-(4-hydroxy-4-methylpentyloxy)-9-(trifluoromethyl)-9H-fluoren-4-yl]-1H-pyrazol-1-yl}-2-methylpropionate (218 mg) was dissolved in ethanol (2.2 ml), 4N aqueous sodium hydroxide (320 μl) was added, and the mixture was stirred at room temperature overnight. The reaction mixture was neutralized with 1N hydrochloric acid, and extracted with ethyl acetate (twice). The obtained organic layer was washed successively with water (twice) and saturated brine. The obtained organic layer was dried over anhydrous magnesium sulfate, the insoluble material was filtered off, and the solvent in the filtrate was evaporated to give the title compound (179 mg).

1. extractionextracted with ethyl acetate (twice)
2. washThe obtained organic layer was washed successively with water (twice) and saturated brine
3. dry with materialThe obtained organic layer was dried over anhydrous magnesium sulfate
4. filtrationthe insoluble material was filtered off
5. customthe solvent in the filtrate was evaporated