反应详情

A mixture of 3 g (0.014 m) of 4-(4-chlorophenyl)-4-hydroxypiperdine, 4.65 g (0.014 m) of 2-(6,11-dihydro-11-oxodibenz[b,e]oxepin-2-yl)ethanol methanesulfonate of Example 1, 1.96 g (0.014 m) of K2CO3, 30 ml of methanol and 30 ml of absolute ethanol was refluxed overnight. The yellow reaction mixture was filtered and evaporated. The residue was partitioned between ethyl acetate and water. The organic phase was dried (Na2SO4), filtered and evaporated to afford a solid. Trituration with ether gave 2.17 g (35%) of 4-(4-chlorophenyl)-1-[2-(6,11-dihydro-11-oxodibenz[b,e]oxepin-2-yl)ethyl]-4-hydroxypiperidine, m.p. 151°-153° C.

1. temperaturewas refluxed overnight
2. filtrationThe yellow reaction mixture was filtered
3. customevaporated
4. customThe residue was partitioned between ethyl acetate and water
5. dry with materialThe organic phase was dried (Na2SO4)
6. filtrationfiltered
7. customevaporated
8. customto afford a solid