反应详情

A mixture of 0.30 gm (1.1 mMol) 5-(N-acetylamino)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)pyrrolo[3,2-b]pyridine and 0.05 gm 10% palladium on carbon in 15 mL ethanol was hydrogenated at room temperature for 18 hours at an initial hydrogen pressure of 50 p.s.i. The reaction mixture was filtered and the filtrate concentrated under reduced pressure. The residue was subjected to silica gel chromatography, eluting with ethyl acetate containing 20% methanol and 1% ammonium hydroxide. Fractions containing product were combined and concentrated under reduced pressure to provide the title compound.

1. filtrationThe reaction mixture was filtered
2. concentrationthe filtrate concentrated under reduced pressure
3. washeluting with ethyl acetate containing 20% methanol and 1% ammonium hydroxide
4. additionFractions containing product
5. concentrationconcentrated under reduced pressure