反应详情

A mixture of 2.5 gm (9.2 mMol) 5-(N-acetylamino)-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine in 40 mL 2N hydrochloric acid was heated at reflux for 1 hour. The reaction mixture was cooled to room temperature, concentrated under reduced pressure, basified (pH ~11) with 2N aqueous sodium hydroxide, concentrated under reduced pressure, and extracted well with 3:1 chloroform:isopropanol. The organic extracts were combined, dried over magnesium sulfate and concentrated under reduced pressure to provide 1.98 gm (93%) of the title compound as a brown solid.

1. temperaturewas heated
2. temperatureat reflux for 1 hour
3. concentrationconcentrated under reduced pressure
4. concentrationconcentrated under reduced pressure
5. extractionextracted well with 3:1 chloroform
6. dry with materialdried over magnesium sulfate
7. concentrationconcentrated under reduced pressure