反应详情

A solution of 20.0 g of 4-[N-methyl-N-(3,5-bistrifluoromethyl-benzoyl)-amino]-5-(naphth-2-yl)-pent-2-enoic acid ethyl ester in 200 ml of tetrahydrofuran is hydrogenated at 20° C. for 2 hours in the presence of 1.0 g of palladium/activated carbon (10%). The reaction mixture is then filtered and concentrated by evaporation. In this way the title compound is obtained in the form of a colourless oil. Rf value=0.50 (hexane/ethyl acetate:1:1). IR(CH2Cl2) cm-1 : 2978, 1729, 1639, 1405, 1339, 1278, 1183, 1141, 903, 849, 820.

1. filtrationThe reaction mixture is then filtered
2. concentrationconcentrated by evaporation