反应详情

1.5 g (5.4 mmol) of 1-(5′-hydroxy-2′-methyl-2-propylbiphenyl-4-yl)-1-propanone, 2.5 g (5.7 mmol) of (3,4-bis(benzoyloxymethyl)benzyl bromide and 750 mg (5.4 mmol) of potassium carbonate are placed in 50 ml of methyl ethyl ketone in a round-bottomed flask and under a stream of nitrogen. The mixture is refluxed overnight and, after cooling, it is filtered through Celite. The filtrate is extracted with water and ethyl acetate. The organic phase is dried over magnesium sulfate, filtered and then evaporated. The residue obtained is purified by chromatography on a column of silica eluted with a mixture of heptane and ethyl acetate (85/15) to give 1.93 g (56%) of the expected product in the form of a dark yellow oil.

1. temperatureThe mixture is refluxed overnight
2. temperatureafter cooling
3. filtrationit is filtered through Celite
4. extractionThe filtrate is extracted with water and ethyl acetate
5. dry with materialThe organic phase is dried over magnesium sulfate
6. filtrationfiltered
7. customevaporated
8. customThe residue obtained
9. customis purified by chromatography on a column of silica
10. washeluted with a mixture of heptane and ethyl acetate (85/15)