huagongshe.com
HRID585759

反应详情

EQUATION

反应方程式

HRID 585759 的结构方程式

REACTANTS

反应物

3
结构：Nc1ccncc1
HCID1727

4-Aminopyridine

C5H6N2

结构：C[n+]1ccccc1Cl.[I-]
HCID167069

2-Chloro-1-methylpyridinium iodide

C6H7ClIN

结构：CC(C)(C)OC(=O)N[C@H]1CCSc2cc(C(=O)O)c(Cl)cc21
HCID59089433

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N[C@H]1CCSc2cc(C(=O)Nc3ccncc3)c(Cl)cc21
HCID59089456

未命名化合物

收率 103.9%

PROCEDURE

实验过程

By a similar reaction operation as in Starting Material Synthetic Example 53 using (S)-4-(tert-butoxycarbonylamino)-6-chlorothiochromane-7-carboxylic acid (250 mg), 4-aminopyridine (68.4 mg) and 2-chloro-1-methylpyridinium iodide (222 mg), the objective (S)-4-(tert-butoxycarbonylamino)-6-chloro-N-(4-pyridyl)thiochromane-7-carboxamide (317 mg) was obtained as a colorless amorphous solid.