HRID586262

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11207603

未命名化合物

结构：CC1(C)OB(c2ccc(F)c(-c3ccccc3C#N)c2)OC1(C)C

HCID11771647

2′-Fluoro-5′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)[1,1′-biphenyl]-2-carbonitrile

C19H19BFNO2

PRODUCTS

生成物

结构：CC(C)(O)c1cnn2c(-c3ccc(F)c(-c4ccccc4C#N)c3)cnc2n1

HCID9947718

未命名化合物

收率 29%

PROCEDURE

实验过程

2′-Fluoro-5′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile was coupled to 2-(7-bromoimidazo[1,2-b][1,2,4]triazin-3-yl)-propan-2-ol in 29% yield using a similar procedure to that described in Example 3, step f, to give a yellow solid: mp 187° C.; 1H NMR (360 MHz, CDCl3) δ 1.71 (6H, s), 3.25 (1H, br s), 7.36-7.84 (5H, m), 8.09-8.16 (2H, m), 8.26 (1H, s), 8.76 (1H, s); MS (ES+) m/z 374 [M+H]+. Anal. Found: C, 67.34; H, 4.30, N. 18.47%. Required for C21H16FN5O: C, 67.55; H, 4.32; N, 18.76%.

WORKUP

后处理

customto give a yellow solid