反应详情

温度

120 °C

A mixture of 3-(2,3-dihydro-1H-indol-5-yl)-1-ethyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (100 mg) and 2-chloro-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazole (101 mg) in NMP (2 mL) was stirred at 120° C. for 10 h, treated with saturated NaHCO3 solution and extracted with AcOEt. The organic layer was dried over MgSO4 and concentrated in vacuo. The residue was dissolved in DMF (2 mL), and then iodomethane (0.022 mL) and Cs2CO3 (0.176 g) were added. The mixture was stirred at room temperature for 3 h, treated with water and extracted with AcOEt. The organic layer was dried over MgSO4 and concentrated in vacuo. The residue was suspended in CH3CN and the precipitate was filtered off. The residue was purified by prep. HPLC, and then chromatographed on silica gel eluting with AcOEt/Hexane. Crystallization from AcOEt/Hexane gave the title compound (12 mg).

1. extractionextracted with AcOEt
2. dry with materialThe organic layer was dried over MgSO4
3. concentrationconcentrated in vacuo
4. dissolutionThe residue was dissolved in DMF (2 mL)
5. additioniodomethane (0.022 mL) and Cs2CO3 (0.176 g) were added
6. stirringThe mixture was stirred at room temperature for 3 h
7. additiontreated with water
8. extractionextracted with AcOEt
9. dry with materialThe organic layer was dried over MgSO4
10. concentrationconcentrated in vacuo
11. filtrationthe precipitate was filtered off
12. customThe residue was purified by prep
13. customHPLC, and then chromatographed on silica gel eluting with AcOEt/Hexane
14. customCrystallization from AcOEt/Hexane