反应详情

4-(Bromomethyl)-6-chloro-3-methoxy-1-trityl-1H-pyrazolo[4,3-c]pyridine (165 mg, 0.318 mmol) was dissolved in THF (4 mL), charged with NMO (112 mg, 0.954 mmol), and stirred at room temperature overnight. The reaction mixture was concentrated in vacuo and the residue was purified by flash chromatography (10-50% EtOAc/hexanes) to give 6-chloro-3-methoxy-1-trityl-1H-pyrazolo[4,3-c]pyridine-4-carbaldehyde. 1H NMR (500 MHz, CDCl3) δ 10.41 (s, 1H), 7.31 (m, 10H), 7.20 (m, 5H), 6.08 (s, 1H), 4.00 (s, 3H).

1. concentrationThe reaction mixture was concentrated in vacuo
2. customthe residue was purified by flash chromatography (10-50% EtOAc/hexanes)