4'-Methoxybiphenyl-4-sulfonyl chloride → 4'-Methoxy-N-[3-(1H-tetrazol-5-yl)phenyl]biphenyl-4-sulfonamide

HRID 589754Notes

Reaction equation

HRID 589754 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([S:15](Cl)(=[O:17])=[O:16])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[NH2:19][C:20]1[CH:21]=[C:22]([C:26]2[NH:30][N:29]=[N:28][N:27]=2)[CH:23]=[CH:24][CH:25]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([S:15]([NH:19][C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([C:26]4[NH:30][N:29]=[N:28][N:27]=4)[CH:21]=3)(=[O:17])=[O:16])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 27947504'-Methoxybiphenyl-4-sulfonyl chlorideHCID 178507542HCID 178507542, compound

Product 1

HCID 1784886334'-Methoxy-N-[3-(1H-tetrazol-5-yl)phenyl]biphenyl-4-sulfonamideYield 79%

Procedure

The product was prepared according to General Procedure 1, described in Example 1, with 4′-methoxy[1,1′-biphenyl]-4-sulfonyl chloride (15.6 mg, 0.055 mmol) and 5-(3-aminophenyl)tetrazole (8.0 mg, 0.050 mmol). The title compound was obtained in 79% yield (16 mg). MS (ESI+) calcd mass for C20H17N5O3S 407.105210, found 407.105280.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-b1795f03a6ae48cf813d6967030468e0
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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