1-Hexanol → HCID 66800178, compound

HRID 589778Notes

Reaction equation

HRID 589778 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([S:10]([NH:13][C:14]3[CH:15]=[C:16]([CH:20]=[CH:21][CH:22]=3)[C:17]([OH:19])=[O:18])(=[O:12])=[O:11])=[C:7]([CH3:23])[C:6]=2[CH:24]=1.[CH2:25](O)[CH2:26][CH2:27][CH2:28][CH2:29][CH3:30]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([S:10]([NH:13][C:14]3[CH:15]=[C:16]([CH:20]=[CH:21][CH:22]=3)[C:17]([O:19][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])=[O:18])(=[O:12])=[O:11])=[C:7]([CH3:23])[C:6]=2[CH:24]=1

Participants

3

Reactant 2

HCID 81031-HexanolHCID 569413063-{[(5-Chloro-3-methyl-1-benzothien-2-yl)sulfonyl]amino}benzoic acid2×

Product 1

HCID 66800178HCID 66800178, compoundYield 71%

Procedure

The product was prepared from 3-{[(5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl]amino}benzoic acid (21 mg, 0.055 mmol) (Intermediate 19) and 1-hexanol (10.2 mg, 0.100 mmol) according to the General Procedure 7, described in Example 107. The title compound was obtained in 71% yield (18.3 mg). 1H NMR (500 MHz, CDCl3) δ ppm 0.87-0.93 (m, 3 H) 1.27-1.36 (m, 4 H) 1.35-1.43 (m, 2 H) 1.65-1.74 (m, 2 H) 2.45 (s, 3 H) 4.26 (t, J=6.71 Hz, 2 H) 6.85 (s, 1 H) 7.36 (dd, J=8.08, 7.68 Hz, 1 H) 7.42 (ddd, J=8.08, 2.35, 1.28 Hz, 1 H) 7.44 (dd, J=8.69, 1.95 Hz, 1 H) 7.71 (dd, J=8.69, 0.55 Hz, 1 H) 7.71-7.72 (m, 1 H) 7.71 (dd, J=1.95, 0.55 Hz, 1 H) 7.84 (ddd, J=7.68, 1.50, 1.28 Hz, 1 H). MS (ESI+) m/z 466 [M+H]+.

Sources & evidence

ORD record
ord-556536c7ee254866aaf10197cec581de
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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