反应详情

温度

20 °C

In a 1000 mL flask was placed methyl 3-{[(2,6-difluorophenyl)sulfonyl]amino}-2-fluorobenzoate (9.64 g, 27.9 mmol) and THF (200 mL) was added. The flask was placed in an ice/water bath and LiHMDS (90 mL, 90 mmol) was added. 2-Chloro-4-methylpyrimidine (4.5 g, 35.0 mmol) in THF (60 mL) was added dropwise via addition funnel. After the addition was complete, the reaction was allowed to warm to 20° C. over 1 h. The THF volume was reduced to half under reduced pressure and then treated with 6N HCl. EtOAc was added and the layers were separated. The aqueous layer was extracted twice with EtOAc and the combined organic layer was washed once with brine, dried over NaSO4, and concentrated. The residue was triturated with EtOAc/ether to afford 8.71 g (71%) of the title compound of Step D. MS (ESI): 442 [M+H]+.

1. customIn a 1000 mL flask was placed
2. customThe flask was placed in an ice/water bath
3. additionAfter the addition
4. customthe layers were separated
5. extractionThe aqueous layer was extracted twice with EtOAc
6. washthe combined organic layer was washed once with brine
7. dry with materialdried over NaSO4
8. concentrationconcentrated
9. customThe residue was triturated with EtOAc/ether