反应详情

To a mixture of methyl(4-methyl-6-((2-methyl-6-(trifluoromethyl)pyridin-3-yl)methoxy)-1-benzothiophen-3-yl)acetate (222.5 mg) and EtOH (5 mL) was added 1N NaOH (1 mL) at room temperature, and the mixture was refluxed for 2 h. The mixture was neutralized with 1N HCl at room temperature and extracted with EtOAc. The organic layer was separated, washed with brine, dried over MgSO4 and concentrated in vacuo. The residue was crystallized from EtOAc-hexane to give the title compound (165 mg).

1. temperaturethe mixture was refluxed for 2 h
2. extractionextracted with EtOAc
3. customThe organic layer was separated
4. washwashed with brine
5. dry with materialdried over MgSO4
6. concentrationconcentrated in vacuo
7. customThe residue was crystallized from EtOAc-hexane