反应详情

To a mixture of methyl(4,7-dimethyl-6-((2-methyl-6-(trifluoromethyl)pyridin-3-yl)methoxy)-1-benzothiophen-3-yl)acetate (124.6 mg), MeOH (2.0 mL) and THF (dry) (2.0 mL) was added 1N NaOH (0.883 mL). The mixture was stirred at room temperature for 2 h. The mixture was concentrated. The residue was neutralized with 1N HCl and extracted with EtOAc. The organic layer was washed with brine, dried over MgSO4, and concentrated in vacuo. The solid was crystallized from EtOAc-hexane to give the title compound (108 mg).

1. concentrationThe mixture was concentrated
2. extractionextracted with EtOAc
3. washThe organic layer was washed with brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated in vacuo
6. customThe solid was crystallized from EtOAc-hexane