反应详情

To a mixture of methyl(4-chloro-6-((1,3-dimethyl-1H-pyrazol-5-yl)methoxy)-1-benzothiophen-3-yl)acetate (162 mg) and EtOH (3 mL) was added 1N NaOH (1 mL) at room temperature, and the mixture was refluxed for 1 h. The mixture was concentrated in vacuo, neutralized with 1N HCl at 0° C. and extracted with EtOAc. The organic layer was separated, washed successively with water and brine, dried over MgSO4 and concentrated in vacuo. The residue was crystallized from EtOAc-hexane to give the title compound (141 mg).

1. temperaturethe mixture was refluxed for 1 h
2. concentrationThe mixture was concentrated in vacuo
3. customneutralized with 1N HCl at 0° C.
4. extractionextracted with EtOAc
5. customThe organic layer was separated
6. washwashed successively with water and brine
7. dry with materialdried over MgSO4
8. concentrationconcentrated in vacuo
9. customThe residue was crystallized from EtOAc-hexane