反应详情

To a mixture of methyl(4,7-dichloro-6-((2-methyl-6-(trifluoromethyl)pyridin-3-yl)methoxy)-1-benzothiophen-3-yl)acetate (124.5 mg), THF (dry) (2.0 mL), and MeOH (2.0 mL) was added 1N NaOH (0.804 mL) at room temperature. The mixture was stirred at room temperature for 5 h. The mixture was neutralized with 1N HCl and concentrated in vacuo. The precipitate was collected by filtration to give a solid. The solid was crystallized from EtOH-hexane to give the title compound (96.6 mg).

1. concentrationconcentrated in vacuo
2. filtrationThe precipitate was collected by filtration
3. customto give a solid
4. customThe solid was crystallized from EtOH-hexane