反应详情

To a mixture of methyl(7-chloro-6-((2,4-dichlorobenzyl)oxy)-1-benzofuran-3-yl)acetate (218.9 mg), MeOH (2.0 mL) and THF (dry) (2.0 mL) was added 1N NaOH (1.643 mL) at room temperature. The mixture was stirred at room temperature for 2 h. The residue was concentrated. The residue was neutralized with 1N HCl, and the mixture was extracted with EtOAc. The combined organic layer was washed with brine, dried over MgSO4, and concentrated in vacuo. The precipitate was collected by filtration, and crystallized from EtOH-hexane to give the title compound (184 mg).

1. concentrationThe residue was concentrated
2. extractionthe mixture was extracted with EtOAc
3. washThe combined organic layer was washed with brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated in vacuo
6. filtrationThe precipitate was collected by filtration
7. customcrystallized from EtOH-hexane