反应详情

To a mixture of methyl 2-(6-((2-chloro-4-((triisopropylsilyl)oxy)benzyl)oxy)-2,3-dihydro-1-benzofuran-3-yl)acetate (5.70 g) and THF (50 mL) cooled with an ice bath was added tetrabutylammonium fluoride (1.0 M THF solution, 14.1 mL). After being stirred for 20 min, the mixture was diluted with brine and EtOAc. The layers were separated, and the aqueous layer was extracted with EtOAc. The combined organic layer was washed with brine, dried over MgSO4 and concentrated. The residue was purified by silica gel column chromatography (EtOAc/hexane) to give the title compound (2.68 g).

1. temperaturecooled with an ice bath
2. customThe layers were separated
3. extractionthe aqueous layer was extracted with EtOAc
4. washThe combined organic layer was washed with brine
5. dry with materialdried over MgSO4
6. concentrationconcentrated
7. customThe residue was purified by silica gel column chromatography (EtOAc/hexane)