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HRID591924

反应详情

EQUATION

反应方程式

HRID 591924 的结构方程式

REACTANTS

反应物

3
结构：CN1CCN(c2ccc(C=O)cc2)CC1
HCID736533

4-(4-methylpiperazin-1-yl)benzaldehyde

C12H16N2O

结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc(N)c2N)[C@H]2C=C[C@@H]1C2
HCID117701912

未命名化合物

结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc3[nH]c(-c4ccc(CN5CCOCC5)cc4)nc23)[C@H]2C=C[C@@H]1C2.O=C(O)C(F)(F)F
HCID178513995

未命名化合物

PRODUCTS

生成物

1
结构：CN1CCN(c2ccc(-c3nc4c(N[C@H]5[C@@H](C(N)=O)[C@@H]6C=C[C@H]5C6)c(Cl)cnc4[nH]3)cc2)CC1.O=C(O)C(F)(F)F
HCID178480652

未命名化合物

收率 88%

PROCEDURE

实验过程

In the same fashion as for Compound III, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 4-(4-Methyl-piperazin-1-yl)-benzaldehyde were reacted to produce the title compound (88%). 1H NMR (d-chloroform): 15.58 (br s, 1H) 8.36 (d, J=9 Hz, 1H), 8.00 (d, J=9 Hz, 2H), 7.78 (s, 1H), 7.02 (d, J=9 Hz, 2H), 6.48 (m, 1H), 6.41 (m, 1H), 5.99 (s, 1H), 5.61 (s, 1H), 5.35 (t, J=9 Hz, 1H), 3.38-3.93 (m, 8H), 3.17 (s, 1H), 3.04 (m, 1H), 3.02 (s, 1H), 2.91 (s, 3H), 2.69 (d, J=9 Hz, 1H), 2.31 (d, J=9 Hz, 1H), 1.67 (d, J=9 Hz, 1H). MS: 479.11 (M+H). HPLC retention time: 1.81 minutes (G Method).