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HRID591925

反应详情

EQUATION

反应方程式

HRID 591925 的结构方程式

REACTANTS

反应物

3
结构：CC(C)(C)OC(=O)N1CCCC(C=O)C1
HCID9964448

tert-Butyl 3-formylpiperidine-1-carboxylate

C11H19NO3

结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc(N)c2N)[C@H]2C=C[C@@H]1C2
HCID117701912

未命名化合物

结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc3[nH]c(-c4ccc(CN5CCOCC5)cc4)nc23)[C@H]2C=C[C@@H]1C2.O=C(O)C(F)(F)F
HCID178513995

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCCC(c2nc3c(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)c(Cl)cnc3[nH]2)C1
HCID178451851

未命名化合物

收率 65%

PROCEDURE

实验过程

In the same fashion as for Compound III, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 3-formyl-piperidine-1-carboxylic acid tert-butyl ester were reacted to produce the title compound (65%). 1H NMR (d-chloroform): 15.20 (br s, 1H), 8.42 (m, 1H), 7.83 (s, 1H), 6.45 (m, 1H), 6.38 (m, 1H), 5.90 (m, 1H), 5.64 (s, 1H), 5.25 (m, 1H), 4.03 (m, 1H), 2.80-3.25 (m, 5H), 2.62 (t, J=8 Hz, 1H), 2.39 (d, J=10 Hz, 2H), 1.32-2.00 (m, 14H). MS: 488.07 (M+H). HPLC retention time: 2.67 minutes (G Method).