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HRID591929

反应详情

EQUATION

反应方程式

HRID 591929 的结构方程式

REACTANTS

反应物

3
结构：COc1cc(N(C)C)ccc1C=O
HCID291350

4-DIMETHYLAMINO-2-METHOXYBENZALDEHYDE

C10H13NO2

结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc(N)c2N)[C@H]2C=C[C@@H]1C2
HCID117701912

未命名化合物

结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc3[nH]c(-c4ccc(CN5CCOCC5)cc4)nc23)[C@H]2C=C[C@@H]1C2.O=C(O)C(F)(F)F
HCID178513995

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc(N(C)C)ccc1-c1nc2c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)c(Cl)cnc2[nH]1
HCID178493178

未命名化合物

收率 52%

PROCEDURE

实验过程

In the same fashion as for Compound III, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 4-Dimethylamino-2-methoxy-benzaldehyde were reacted to produce the title compound (52%). 1H NMR (d-chloroform): 13.60 (br s, 1H), 8.16 (d, J=9 Hz, 1H), 7.79 (s, 1H), 7.44 (br s, 1H), 6.35-6.50 (m, 3H), 6.24 (d, J=2 Hz, 1H), 5.94 (s, 1H), 5.43 (t, J=8 Hz, 1H), 5.31 (br s, 1H), 4.16 (s, 3H), 3.27 (s, 1H), 3.10 (s, 6H), 3.02 (s, 1H), 2.72 (d, J=8 Hz, 1H), 2.35 (d, J=9 Hz, 1H), 1.70 (d, J=10 Hz, 1H). MS: 454.07 (M+H). HPLC retention time: 2.61 minutes (G Method).