反应详情

In the same fashion as for Compound III, (1R,2R,3S,4S)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 3-Morpholin-4-yl-benzaldehyde were reacted to produce the title compound (11%). 1H NMR (d-chloroform): 16.12 (br s, 1H), 8.42 (d, J=9 Hz, 1H), 7.83 (s, 1H), 7.74 (s, 1H), 7.64 (d, J=8 Hz, 1H), 7.44 (t, J=8 Hz, 1H), 7.07 (d, J=8 Hz, 1H), 6.50 (m, 1H), 6.42 (m, 1H), 5.90 (br s, 1H), 5.65 (br s, 1H), 5.40 (t, J=8 Hz, 1H), 3.94 (m, 4H), 3.34 (m, 4H), 3.18 (s, 1H), 3.07 (s, 1H), 2.69 (d, J=8 Hz, 1H), 2.33 (d, J=9 Hz, 1H), 1.69 (d, J=9 Hz, 1H). MS: 465.15 (M+H). HPLC retention time: 2.39 minutes (G Method).