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HRID591938

反应详情

EQUATION

反应方程式

HRID 591938 的结构方程式

REACTANTS

反应物

3
结构：COc1cc(N2CCC(N3CCOCC3)CC2)ccc1C=O
HCID117701815

未命名化合物

结构：NC(=O)[C@H]1[C@@H](Nc2c(Cl)cnc(N)c2N)[C@@H]2C=C[C@H]1C2
HCID117701849

未命名化合物

结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc3[nH]c(-c4ccc(CN5CCOCC5)cc4)nc23)[C@H]2C=C[C@@H]1C2.O=C(O)C(F)(F)F
HCID178513995

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc(N2CCC(N3CCOCC3)CC2)ccc1-c1nc2c(N[C@@H]3[C@H](C(N)=O)[C@H]4C=C[C@@H]3C4)c(Cl)cnc2[nH]1
HCID178492998

未命名化合物

收率 8%

PROCEDURE

实验过程

In the same fashion as for Compound III, (1R,2R,3S,4S)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 2-Methoxy-4-(4-morpholin-4-yl-piperidin-1-yl)-benzaldehyde were reacted to produce the title compound (8%). 1H NMR (d-6 DMSO): 12.26 (br s, 1H), 9.70 (br s, 1H), 8.02 (m, 1H), 7.79 (s, 1H), 7.42 (br s, 1H), 7.26 (s, 1H), 6.78 (d, J=9 Hz, 1H), 6.66 (s, 1H), 6.38 (s, 2H), 5.17 (m, 1H), 4.11 (m, 2H), 4.03 (m, 2H), 4.00 (s, 3H), 3.68 (m, 2H), 3.48 (m, 4H), 3.12 (m, 2H), 2.92-2.77 (m, 3H), 2.63 (d, J=8 Hz, 1H), 2.24 (m, 1H), 2.13 (m, 2H), 1.68 (m, 2H), 1.40 (d, J=9 Hz, 1H). MS: 578.20 (M+H). HPLC retention time: 1.92 minutes (G Method).