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HRID591943

反应详情

EQUATION

反应方程式

HRID 591943 的结构方程式

REACTANTS

反应物

3
结构：COc1cc(N2CCOCC2)ccc1C=O
HCID976800

2-Methoxy-4-morpholin-4-yl-benzaldehyde

C12H15NO3

结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc(N)c2N)[C@H]2C=C[C@@H]1C2
HCID117701912

未命名化合物

结构：NC(=O)[C@@H]1[C@H](Nc2c(Cl)cnc3[nH]c(-c4ccc(CN5CCOCC5)cc4)nc23)[C@H]2C=C[C@@H]1C2.O=C(O)C(F)(F)F
HCID178513995

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc(N2CCOCC2)ccc1-c1nc2c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)c(Cl)cnc2[nH]1
HCID178493033

未命名化合物

收率 65%

PROCEDURE

实验过程

In the same fashion as for Compound III, (1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide and 2-methoxy-4-morpholin-4-yl-benzaldehyde were reacted to produce the title compound (65%). 1H NMR (d-chloroform): 13.88 (br s, 1H), 8.25 (m, 2H), 7.77 (s, 1H), 7.18 (s, 1H), 7.07 (d, J=7 Hz, 1H), 6.42 (m, 3H), 5.81 (s, 1H), 5.29 (t, J=7 Hz, 1H), 4.53 (d, J=9 Hz, 1H), 4.10-3.94 (m, 10H), 3.68 (m, 1H), 3.35 (m, 1H), 3.16 (s, 1H), 2.92 (s, 1H), 2.77 (d, J=8 Hz, 1H), 2.38 (d, J=9 Hz, 1H), 1.63 (d, J=9 Hz, 1H). MS: 509.16 (M+H). HPLC retention time: 1.82 minutes (G Method).