反应详情

A mixture of 1-(4-(benzyloxy)benzyl)-6-(2,6-dimethoxyphenyl)piperidin-2-one (74 mg; 0.17 mmol), and 10% Pd(C) (35 mg) in anh. EtOH (3 ml) was stirred at rt, under hydrogen atmosphere (1 atm), for 15 h. Filtration over a pad of celite, concentration to dryness under reduced pressure, and additional drying under HV afforded 6-(2,6-dimethoxyphenyl)-1-(4-hydroxybenzyl)piperidin-2-one as a yellow oil. LC-MS (conditions E): tR=0.62 min.; [M+H]+: 342.20 g/mol.

1. filtrationFiltration
2. concentrationover a pad of celite, concentration to dryness under reduced pressure
3. customadditional drying under HV