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To a solution of ethyl 3-(2,6-dichloropyridin-3-yl)propanoate in THF (12 mL) was added LiBH4 (88 mg, 4.03 mmol). The resultant mixture was stirred at ambient temperature for 2.5 h then was cooled to 0° C. and carefully quenched by addition of saturated NH4Cl(aq) solution. The reaction mixture was diluted with EtOAc and the organic layer washed successively with H2O (1×) and brine (1×). The organic extract was dried over MgSO4, filtered, and concentrated in vacuo. Purification by silica gel column chromatography using a gradient of 0-60% EtOAc/Hexanes as eluent provided the title compound. 1H NMR δ (ppm) (CHCl3-d): 7.58 (1H, d, J=7.92 Hz), 7.25 (1H, d, J=7.80), 3.73 (2H, q, J=5.48 Hz), 2.85 (2H, t, J=7.76 Hz), 1.95˜1.88 (2H, m), 1.42 (1H, m). MS (M+H)+: 205.

1. customcarefully quenched by addition of saturated NH4Cl(aq) solution
2. additionThe reaction mixture was diluted with EtOAc
3. washthe organic layer washed successively with H2O (1×) and brine (1×)
4. extractionThe organic extract
5. dry with materialwas dried over MgSO4
6. filtrationfiltered
7. concentrationconcentrated in vacuo
8. customPurification by silica gel column chromatography