Potassium Carbonate → 3-bromo-2-methoxy-5-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine

Br2 (2.00 ml, 39.2 mmol) was added to a mixture of 2-methoxy-5-methyl-7-(trifluoroacetyl)-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine (113 mg, 392 μmol), Na2HPO4 buffer (40 ml) and MeOH (5 ml). After stirring for 1 h at ambient temperature, the reaction mixture was parted between EtOAc and NaHCO3. The organic phase was washed with brine, dried over Na2SO4 and concentrated in vacuo. Chromatographic purification rendered 152 mg (99%) of 3-bromo-2-methoxy-5-methyl-7-(trifluoroacetyl)-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine. 1H-NMR (CDCl3) δ 7.61 (s, 1H), 4.18-3.82 (m, 5H), 3.63 (m, 1H), 3.56-3.36 (m, 1H), 3.24 (m, 1H), 3.10 (m, 2H), 1.33 (m, 3H) ppm. A mixture of 3-bromo-2-methoxy-5-methyl-7-(trifluoroacetyl)-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine (52.0 mg, 142 μmol) and K2CO3 (100 mg) in MeOH (20 ml) was heated at reflux for 1.5 h. The reaction mixture was parted between EtOAc and NaHCO3. The organic phase was washed with brine, dried over Na2SO4 and concentrated in vacuo. Chromatographic purification rendered 37.5 mg (97%) of 3-bromo-2-methoxy-5-methyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-d]azepine. 1H-NMR (CDCl3) δ 7.55 (s, 1H), 3.97 (s, 3H), 3.10-2.91 (m, 6H), 2.74 (dd, 1H), 1.31 (d, 3H) ppm.

1. washThe organic phase was washed with brine
2. dry with materialdried over Na2SO4
3. concentrationconcentrated in vacuo
4. customChromatographic purification
5. temperaturewas heated
6. temperatureat reflux for 1.5 h
7. washThe organic phase was washed with brine
8. dry with materialdried over Na2SO4
9. concentrationconcentrated in vacuo
10. customChromatographic purification

ORD record

ord-bfb7cec7fe034f62af6a3125fcf30a34

Source dataset

uspto-grants-2011_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07897595B2