反应详情

tert-Butyl 4-((4-chlorophenethyl)(4-(methoxycarbonyl)benzyl)amino)piperidine-1-carboxylate obtained in Step 1 was dissolved in MeOH (5 mL/mmol), NaOH (5 eqs) (as a 0.5 N aqueous solution) was added and the reaction mixture was stirred at room temperature for 15 hours.). pH of the reaction was made neutral by careful addition of 0.5 N HCl, and methanol was removed in vacuo. The precipitated product was filtered off, washed several times with acetone/diethyl ether mixture (1:2 v/v) and dried in the air. It was found to be of sufficient purity to be used in the next step without further purification.

1. customwas removed in vacuo
2. filtrationThe precipitated product was filtered off
3. washwashed several times with acetone/diethyl ether mixture (1:2 v/v)
4. customdried in the air
5. customto be used in the next step without further purification