反应详情

To a solution of 1-[2-(tertbutyldimethylsilanyloxy)ethyl]-N-(4-(2-fluoro-4-iodophenylamino)-1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)cyclopropanesulfonamide (20 mg, 0.032 mmol) in THF (2 mL) at 0° C. is added 1N HCl (0.128 mL. 0.128 mmol). The ice-bath is removed after 30 minutes and the solution stirred at room temperature for 45 minutes. Then the solution is cooled to 0° C., saturated NaHCO3 (3 mL) solution is added, and extracted with ethyl acetate (3×5 mL). The combined organic layers are concentrated under reduced pressure to give the title compound.

1. customThe ice-bath is removed after 30 minutes
2. temperatureThen the solution is cooled to 0° C.
3. additionsaturated NaHCO3 (3 mL) solution is added
4. extractionextracted with ethyl acetate (3×5 mL)
5. concentrationThe combined organic layers are concentrated under reduced pressure