反应详情

This compound was synthesized in an analogous manner to Example 32 but using 4-methylpentanenitrile (commercially available from TCI America Organic Chemicals Order Number M0458) instead of acetonitrile in the preparation of allyl 4-isobutyl-3-(isoquinolin-6-yl)isoxazol-5-ylcarbamate according to Scheme 6 instead of allyl 3-(isoquinolin-6-yl)isoxazol-5-ylcarbamate. MS m/z: 440 (M+1); 1H NMR (400 MHz, CD3OD) δ ppm 9.73 (s, 1H), 8.61 (d, J=6.65 Hz, 1H), 8.53-8.57 (m, 1H), 8.43 (s, 2H), 8.15 (dd, J=8.61, 1.56 Hz, 1H), 0.57 (d, J=7.43 Hz, 1H), 7.40 (d, J=8.22 Hz, 1H), 7.25 (s, 1H), 7.15 (t, J=7.43 Hz, 1H), 7.06 (t, J=7.24 Hz, 1H), 3.78-3.83 (m, 1H), 3.63-3.68 (m, 2H), 3.22-3.28 (m, 1H), 3.10-3.16 (m, 1H), 2.37 (d, J=7.43 Hz, 2H), 1.58 (dt, J=13.60, 6.70 Hz, 1H), 0.76 (d, J=6.65 Hz, 6H).

1. customThis compound was synthesized in an analogous manner to Example 32